In light of the COVID-19 pandemic, this research report covers the impact of pandemics on transportation agencies of all sizes and how best to approach the challenges created. The guide identifies several challenges including public fear and loss of confidence in safety, morale and trust issues with employees, loss of team building and team interactions, stress and other psychological impacts, funding and increased expenses, and other unintended consequences of response actions. It highlights a series of key questions to ask when developing a response to pandemic events, and it runs through emergency management plays for a slew of different areas.